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Kathryn E. Dickerson, MD $$

Pediatric Hematologist/Oncologist

Assistant Professor at UT Southwestern Medical Center

Languages Spoken:
English Spanish

Locations

UT Southwestern Pediatric Group

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Biography

Kathryn E. Dickerson, M.D., M.S.C.S is an Assistant Professor in the Department of Pediatrics, Division of Hematology and Oncology, and 2015 Translational Research Scholar in the UTSW Center for Translational Medicine.

She earned her undergraduate degree in Biochemistry with a minor in Spanish from Indiana University. Before attending medical school, she completed a post-baccalaureate research training program at the NIH working in the laboratory of Dr. Lee Weinstein. She returned to Indiana University to earn her medical degree, working in the laboratory of Dr. Nadia Carlesso. She completed her pediatric residency training in an integrated research pathway at The Ohio State University/Nationwide Children's Hospital, working in the laboratory of Dr. Michael Caligiuri. She completed her fellowship in pediatric hematology/oncology here at UT Southwestern and was mentored in her research on epigenetic regulation of myeloid malignancies and treatment resistance at by Dr. Jian Xu, in his lab at the Children's Resaerch Institute. While in her fellowship and on into her early faculty appointment, Dr. Dickerson earned a Master of Science in Clinical Sciences from the Center for Translational Medicine as an NIH KL2 scholar.

Dr. Dickerson's clinical interest is pediatric hematology with an emphasis on bone marrow failure disorders and cancer predisposition, as well as thalassemia/dyserythropoietic anemias. Her research interest is in predisposition and transformation to myeloid malignancies: acute myelogenous leukemia (AML), myeloproliferative disorders (MPD), and myelodysplastic syndromes (MDS) in children. Dr. Dickerson conducts an investigator-initiated study to evaluate childhood cancer survivors for clonal hematopoiesis and inflammation, as well as many industry/consortia-sponsored studies in bone marrow failure and other rare hematologic diseases.

Fun Facts

  • I’m from Indiana and have lived in Dallas since 2014. I’m a lover of college sports and will root for any BigTen school.
  • I'm admirer of the great outdoors- I enjoy hiking and camping with my partner, Stephen and our Labradors Tally and Rex.
  • I'm an avid traveler and foodie!

Education and Training

Medical School
Indiana University School of Medicine-Indianapolis (2011)
Residency
Nationwide Children's Hospital (2014), Pediatrics
Fellowship
UT Southwestern - Childrens Medical Center (2017), Pediatric Hematology/Oncology
Board Certification
American Board of Pediatrics/Hematology-Oncology

Conditions

  • Bone marrow failure
  • Leukemia predisposition

  • Research Interests

    • Bone marrow failure disorders and cancer predisposition
    • Epigenetics
    • Myeloproliferative disorders
    • Myelodysplastic syndrome
    • Malignant transformation in inherited bone marrow failure (BMF) syndromes
    • Acute myelogenous leukemia

  • Publications

    • Botten GA, Zhang Y, Dudnyk K, Kim YJ, Liu X, Sanders JT, Imanci A, Droin N, Cao H, Kaphle P, Dickerson KE, Kumar KR, Chen M, Chen W, Solary E, Ly P, Zhou J, Xu J. Structural variation cooperates with permissive chromatin to control enhancer hijacking-mediated oncogenic transcription. Blood. 2023 Jul 27;142(4):336-351. doi: 10.1182/blood.2022017555. PMID: 36947815.
    • Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J. Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. Cancer Discov. 2023 Jan 9;13(1):170-193. doi: 10.1158/2159-8290.CD-21-1661. PMID: 36222845; PMCID: PMC9827114.
    • Lee NCJ, Demir YK, Ashraf B, Ibrahim I, Bat T, Dickerson KE. Immature Platelet Fraction as a Biomarker for Disease Severity in Pediatric Respiratory Coronavirus Disease 2019. J Pediatr. 2022 Dec;251:187-189. doi: 10.1016/j.jpeds.2022.07.035. Epub 2022 Aug 6. PMID: 35944718; PMCID: PMC9356758.
    • Liu Y, Gu Z, Cao H, Kaphle P, Lyu J, Zhang Y, Hu W, Chung SS, Dickerson KE, Xu J. Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation. Nat Commun. 2021 Nov 3;12(1):6323. doi: 10.1038/s41467-021-26582-4. PMID: 34732703; PMCID: PMC8566485.
    • Heeney MM, Berhe S, Campagna DR, Oved JH, Kurre P, Shaw PJ, Teo J, Shanap MA, Hassab HM, Glader BE, Shah S, Yoshimi A, Ameri A, Antin JH, Boudreaux J, Briones M, Dickerson KE, Fernandez CV, Farah R, Hasle H, Keel SB, Olson TS, Powers JM, Rose MJ, Shimamura A, Bottomley SS, Fleming MD. SLC25A38 congenital sideroblastic anemia: Phenotypes and genotypes of 31 individuals from 24 families, including 11 novel mutations, and a review of the literature. Hum Mutat. 2021 Nov;42(11):1367-1383. doi: 10.1002/humu.24267. Epub 2021 Aug 5. PMID: 34298585; PMCID: PMC8511274.
    • Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M Jr, Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, Xu J. Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Nat Genet. 2021 May;53(5):672-682. doi: 10.1038/s41588-021-00829-8. Epub 2021 Apr 8. PMID: 33833453; PMCID: PMC8270111.
    • Pulsipher MA, Lehmann LE, Bertuch AA, Sasa G, Olson T, Nakano T, Gilio A, Burroughs LM, Lipton JM, Huang JN, Dickerson K, Bertaina A, Zhuang C, Malsch M, Fleming M, Weller E, Shimamura A, Williams DA. A study assessing the feasibility of randomization of pediatric and young adult patients between matched unrelated donor bone marrow transplantation and immune-suppressive therapy for newly diagnosed severe aplastic anemia: A joint pilot trial of the North American Pediatric Aplastic Anemia Consortium and the Pediatric Transplantation and Cellular Therapy Consortium. Pediatr Blood Cancer. 2020 Oct;67(10):e28444. doi: 10.1002/pbc.28444. Epub 2020 Aug 9. PMID: 32776425; PMCID: PMC9533334.
    • Nakano TA, Lau BW, Dickerson KE, Wlodarski M, Pollard J, Shimamura A, Hofmann I, Sasa G, Elghetany T, Cada M, Dror Y, Ding H, Allen SW, Hanna R, Campbell K, Olson TS. Diagnosis and treatment of pediatric myelodysplastic syndromes: A survey of the North American Pediatric Aplastic Anemia Consortium. Pediatr Blood Cancer. 2020 Oct;67(10):e28652. doi: 10.1002/pbc.28652. Epub 2020 Aug 11. PMID: 32779892.
    • Gu Z, Dickerson KE, Xu J. Therapy Response and Outcome Explained by Leukemia Cell of Origin. Cancer Discov. 2020 Oct;10(10):1445-1447. doi: 10.1158/2159-8290.CD-20-1080. PMID: 33004477.
    • Montiel-Esparza R, Reys B, Rogers ZR, Evans AS, Wysocki CA, Timmons C, Dickerson KE. Connecting the Dots From Fever of Unknown Origin to Myelodysplastic Syndrome: GATA2 Haploinsufficiency. J Pediatr Hematol Oncol. 2020 Jul;42(5):e365-e368. doi: 10.1097/MPH.0000000000001505. PMID: 31033783.
    • Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, Dickerson KE, Chen M, Chen W, Shao Z, Ni M, Xu J. Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. Cancer Discov. 2020 May;10(5):724-745. doi: 10.1158/2159-8290.CD-19-1128. Epub 2020 Mar 18. PMID: 32188707; PMCID: PMC7196497.
    • Li K, Liu Y, Cao H, Zhang Y, Gu Z, Liu X, Yu A, Kaphle P, Dickerson KE, Ni M, Xu J. Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing. Nat Commun. 2020 Jan 24;11(1):485. doi: 10.1038/s41467-020-14362-5. PMID: 31980609; PMCID: PMC6981169.
    • Dickerson KE, Menon NM, Zia A. Abnormal Uterine Bleeding in Young Women with Blood Disorders. Pediatr Clin North Am. 2018 Jun;65(3):543-560. doi: 10.1016/j.pcl.2018.02.008. PMID: 29803282; PMCID: PMC5978747.
    • Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J. Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation. Cancer Discov. 2019 Sep;9(9):1228-1247. doi: 10.1158/2159-8290.CD-19-0152. Epub 2019 Jun 12. PMID: 31189531; PMCID: PMC6726547.
    • Bernot KM, Nemer JS, Santhanam R, Liu S, Zorko NA, Whitman SP, Dickerson KE, Zhang M, Yang X, McConnell KK, Ahmed EH, Muñoz MR, Siebenaler RF, Marcucci GG, Mundy-Bosse BL, Brook DL, Garman S, Dorrance AM, Zhang X, Zhang J, Lee RJ, Blum W, Caligiuri MA, Marcucci G. Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease. Blood. 2013 Nov 28;122(23):3778-83. doi: 10.1182/blood-2013-06-507426. Epub 2013 Oct 1. PMID: 24085765; PMCID: PMC3843236.
    • Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nat Cell Biol. 2017 Jun;19(6):626-638. doi: 10.1038/ncb3527. Epub 2017 May 15. PMID: 28504707; PMCID: PMC5771482.
    • Chen M, Feng HZ, Gupta D, Kelleher J, Dickerson KE, Wang J, Hunt D, Jou W, Gavrilova O, Jin JP, Weinstein LS. G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. Am J Physiol Cell Physiol. 2009 Apr;296(4):C930-40. doi: 10.1152/ajpcell.00443.2008. Epub 2009 Jan 21. PMID: 19158402; PMCID: PMC2670650.
    • Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, Cao H, Ni M, Liu Y, Gu Z, Dickerson KE, Xie S, Hon GC, Xuan Z, Zhang MQ, Shao Z, Xu J. In Situ Capture of Chromatin Interactions by Biotinylated dCas9. Cell. 2017 Aug 24;170(5):1028-1043.e19. doi: 10.1016/j.cell.2017.08.003. PMID: 28841410; PMCID: PMC6857456.
    • Bernot KM, Siebenaler RF, Whitman SP, Zorko NA, Marcucci GG, Santhanam R, Ahmed EH, Ngangana M, McConnell KK, Nemer JS, Brook DL, Kulp SK, Chen CS, Frankhouser D, Yan P, Bundschuh R, Zhang X, Dorrance AM, Dickerson KE, Jarjoura D, Blum W, Marcucci G, Caligiuri MA. Toward personalized therapy in AML: in vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML. Leukemia. 2013 Dec;27(12):2379-82. doi: 10.1038/leu.2013.147. Epub 2013 May 10. PMID: 23660685; PMCID: PMC3864138.
    • Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, Gupta D, Lai EW, Pacak K, Gavrilova O, Weinstein LS. Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell Metab. 2009 Jun;9(6):548-55. doi: 10.1016/j.cmet.2009.05.004. PMID: 19490909; PMCID: PMC2698878.
    • Dickerson KE, Menon NM, Zia A. Abnormal Uterine Bleeding in Young Women with Blood Disorders. Pediatr Clin North Am. 2018 Jun;65(3):543-560. doi: 10.1016/j.pcl.2018.02.008. PMID: 29803282; PMCID: PMC5978747.

  • Professional Activities

    • American Association for Cancer Research (2012)
    • American Academy of Pediatrics (2011)
    • The American Society of Hematology (2014)
    • American Society of Clinical Oncology/American Society of Pediatric Hematology Oncology (2014)

  • Awards and Honors

    • Texas Monthly Super Doctors, Rising Star (2020)
    • Hyundai Hope on Wheels Young Investigator Award (2017)
    • Children's Cancer Fund "Call for Cure" Award Recipient (2017)
    • Certificate in Academic Medicine (2014), Nationwide Children's Hospital
    • Certificate in Global Health (2014), Nationwide Children's Hospital
    • Community Service Award (2011), Indiana University School of Medicine
    • E. Jane Brownley Award (2011), Department of Pediatrics, Indiana University School of Medicine
    • Member, Gold Humanism Honorary Society (2010)
    • Red Shoes Award (2010), Riley Hospital for Children
    • Post-Baccalaureate Intramural Research Training Award (2006), National Institutes of Health/National Institute of Diabetes, Digestive, and Kidney disorders, Dr. Lee Weinstein Laboratory
    • Member, Phi Beta Kappa (2005)

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